Article

METTL16 promotes taxane resistance in Triple-Negative Breast Cancer through m <sup>6</sup> A-dependent translational upregulation of ABCB1

2026-03-13

Abstract excerpt

Triple-negative breast cancer (TNBC) commonly develops resistance to taxane-based chemotherapy, resulting in recurrence and poor clinical outcomes. Defining the molecular mechanisms that sustain chemoresistance is essential for improving therapeutic efficacy. Using unbiased insertional mutagenesis, we identified the RNA methyltransferase METTL16 as a previously unrecognized epi-transcriptomic driver of taxane resi...

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Literature Corpus work: 13f7d43a-4d8f-53d7-b8ea-b8c27686f851
DOI: 10.64898/2026.03.11.710933

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