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Article

Acquired resistance to PRMT5 inhibition induces concomitant collateral sensitivity to paclitaxel.

Proceedings of the National Academy of Sciences of the United States of America - 24 Aug 2021

Mueller Helen S, Fowler Colin E, Dalin Simona, Moiso Enrico, Udomlumleart Tee, Garg Salil, Hemann Michael T, Lees Jacqueline A

Abstract excerpt

Epigenetic regulators play key roles in cancer and are increasingly being targeted for treatment. However, for many, little is known about mechanisms of resistance to the inhibition of these regulators. We have generated a model of resistance to inhibitors of protein arginine methyltransferase 5 (PRMT5). This study was conducted in KrasG12D;Tp53-null lung adenocarcinoma (LUAD) cell lines. Resistance to PRMT5...

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Adenocarcinoma of Lung
Drug Resistance, Neoplasm
Drug Synergism
Epigenesis, Genetic
Gene Knockdown Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein-Arginine N-Methyltransferases

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Identifiers

PMID: 34408017
DOI: 10.1073/pnas.2024055118
PMCID: PMC8403834

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