Back to search

Article

Fractional-Order Observer Design for State Estimation of DNA Damage Dynamics in BRCA1/2-Deficient Cells under PARP Inhibition

2026-04-29

Abstract excerpt

<title>Abstract</title> <p> This paper develops a fractional-order observer framework for the estimation of hidden DNA-damage dynamics in <italic>BRCA1</italic> / <italic>BRCA2</italic> -deficient cells under PARP inhibition. A biologically motivated Caputo fractional-order model is introduced to describe the evolution of three latent states: single-strand DNA breaks, double-strand DNA breaks, and the fracti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
13c68347-96fd-5587-8b23-90b47272b57d
DOI
10.21203/rs.3.rs-9460528/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Fractional-Order Observer Design for State Estimation of DNA Damage Dynamics in BRCA1/2-Deficient Cells under PARP InhibitionDOI 10.21203/rs.3.rs-9460528/v1
Dynamics of p53 and NF-κB regulation in response to DNA damage and identification of target proteins suitable for therapeutic intervention.Semantic proximity
GENAVOS: A New Tool for Modelling and Analyzing Cancer Gene Regulatory Networks Using Delayed Nonlinear Variable Order Fractional SystemSemantic proximity
Derivation and theoretical validation of fractional quasi-steady state approximation (fQSSA) for target-mediated drug disposition models with memory effectsSemantic proximity
On the Observability and Structural Identifiability of Radiobiological Models and the Case for Latent-State Adaptive ControlSemantic proximity
Fractional-Order Framework for Gambling Dynamics with Delay and Control StrategiesSemantic proximity
Pharmacodynamic model of PARP1 inhibition and global sensitivity analyses can lead to cancer biomarker discoverySemantic proximity
Microsatellite Instability Detection: The Current Standards, Limitations, and MisinterpretationsSemantic proximity
Data-Driven Mechanistic Computational Modeling of Human Cell Cycle Phases for Defining Inhibitor Combinations in SilicoSemantic proximity
Select a neighboring publication to make it the new centre.