Article

Ionic environment and nutrients affect the <i>cysB</i> -dependent conditional susceptibility of <i>E. coli</i> to mecillinam

2025-09-27

Abstract excerpt

<h4>ABSTRACT</h4> Antibiotic efficacy is influenced by environmental context. Urinary E. coli isolates lacking a functional cysB gene have been shown to be resistant to the β -lactam antibiotic mecillinam under high-osmolarity conditions, suggesting that increased fluid intake might synergize with drug treatment. In this study, we further explore E. coli susceptibility to mecillinam across growth conditions....

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Literature Corpus work: 13884610-471c-5c9f-910e-9940908cc633
DOI: 10.1101/2025.09.27.678940

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