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Article

Reversion of High-level Mecillinam Resistance to Susceptibility in Escherichia coli During Growth in Urine.

EBioMedicine - 1 Sept 2017

Thulin Elisabeth, Thulin Måns, Andersson Dan I

Abstract excerpt

Mecillinam (amdinocillin) is a β-lactam antibiotic used to treat uncomplicated urinary tract infections (UTIs). We have previously shown that inactivation of the Escherichia coli cysB gene is the major cause of mecillinam resistance (MecR) in clinical isolates. In this study, we used different E. coli strains (laboratory and clinical isolates) that were MecR due to cysB mutations to determine how mecillinam...

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Identifiers

PMID: 28855073
DOI: 10.1016/j.ebiom.2017.08.021
PMCID: PMC5605379

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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