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Multiparametric Profiling of Circulating Immune Cells Identifies an Expansion of CD25high Switched Memory B Cells in Osteoarthritis

14 Apr 2025

Abstract excerpt

Objective Osteoarthritis (OA) is a chronic, debilitating disease with no available disease‐modifying drugs. Biomarker identification in patients with OA has hitherto been limited to serum proteins and bulk epigenomic feature identification. Methods Peripheral blood mononuclear cells (PBMCs) from 21 healthy donors, 17 patients with OA, and 10 patients with degenerative meniscal tears (DMTs) were immunophenotyped...

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PMID: 40229860
DOI: 10.1002/art.43186

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