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Oncolytic Reovirus mediates innate-driven SARS-CoV-2 elimination in the absence of cell toxicity

2025-12-17

Abstract excerpt

Interplay between type I interferon (IFN) driven innate responses and viral antagonism strongly influences SARS-CoV-2 transmission and the COVID-19 disease course. Hence, variant adaptation includes diminished induction of IFN stimulated genes (ISG) and/or evasion of their effector functions. Exogenous IFN treatment “rewires” innate responses to drive virus elimination, yet therapeutic trials to date have been unr...

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Literature Corpus work
134a78f4-a2f3-50ee-a833-0432c447db2a
DOI
10.64898/2025.12.17.694833
Open publication

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Oncolytic Reovirus mediates innate-driven SARS-CoV-2 elimination in the absence of cell toxicityDOI 10.64898/2025.12.17.694833
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