Article

Single Cell Transcriptomic Landscape of Diabetic Foot Ulcers

2021-03-12

Abstract excerpt

To understand the diabetic wound healing microenvironment, we profiled 174,962 single cells from foot, forearm, and PBMCs using single-cell RNA sequencing (scRNASeq) approach. Our analysis shows enrichment of a unique population of fibroblasts overexpressing MMP1, MMP3, MMP11, HIF1A, CHI3L1 , and TNFAIP6 genes and M1 macrophage polarization in the DFU patients with healing wounds. Further, scRNASeq of spatially...

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Literature Corpus work: b9b88610-5171-550b-bd8e-cbf9a24ee936
DOI: 10.1101/2021.03.11.434413

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