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Article

Single cell transcriptomic landscape of diabetic foot ulcers

10 Jan 2022

Abstract excerpt

Diabetic foot ulceration (DFU) is a devastating complication of diabetes whose pathogenesis remains incompletely understood. Here, we profile 174,962 single cells from the foot, forearm, and peripheral blood mononuclear cells using single-cell RNA sequencing. Our analysis shows enrichment of a unique population of fibroblasts overexpressing MMP1, MMP3, MMP11, HIF1A, CHI3L1, and TNFAIP6 and increased M1 macrophage...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35013299
DOI: 10.1038/s41467-021-27801-8

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