Article

Clock Modulation by Naringenin via RORα Suppresses Lipogenesis and Promotes Adipose Tissue Browning

2025-09-02

Abstract excerpt

The circadian clock orchestrates adipocyte development and lipid remodeling, with its disruption leading to the development of obesity and insulin resistance. Here we demonstrate that the flavonoid compound naringenin displays clock modulatory activity via RORα that suppresses adipocyte lipid storage while promoting browning. In adipogenic progenitors, naringenin activates RORα with induction of clock gene express...

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Literature Corpus work: 132bd3db-988d-5a47-abdd-dcb71ac263be
DOI: 10.1101/2025.08.28.672947

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