Article

Quercetin and Fisetin activate circadian clock via RORα and inhibit adipocyte growth

2026-05-01

Abstract excerpt

The circadian clock maintains temporal control of metabolic processes and exerts a key role in adipocyte development. Discovery of clock-modulatory compounds may provide new avenues for metabolic disease therapy. Here we report the identification of flavonoid compounds, Quercetin and Fisetin, as clock-activating molecules with direct inhibitory action on adipogenesis and adipocyte lipid metabolism. Quercetin and F...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2b87e42d-6cc7-5fd0-ad3b-e33344ec746f
DOI: 10.64898/2026.04.28.721484

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Quercetin and Fisetin activate circadian clock via RORα and inhibit adipocyte growthDOI 10.64898/2026.04.28.721484Read

Evidence for Quercetin as a Dietary Supplement for the Treatment of Cardio-Metabolic Diseases in Pregnancy: A Review in Rodent ModelsSemantic proximity Read

Nuclear Receptor RORα/γ: Exciting Modulators in Metabolic Syndrome and Related DisordersSemantic proximity Read

Natural compounds regulate energy metabolism by the modulating the activity of lipid-sensing nuclear receptors.Semantic proximity Read

Clock Modulation by Naringenin via RORα Suppresses Lipogenesis and Promotes Adipose Tissue BrowningSemantic proximity Read

Anti-Inflammatory Mechanisms of Dietary Flavones: Tapping into Nature to Control Chronic Inflammation in Obesity and CancerSemantic proximity Read

Rebamipide treatment ameliorates obesity phenotype by regulation of immune cells and adipocytes.Semantic proximity Read

Natural Products and Obesity: A Focus on the Regulation of Mitotic Clonal Expansion during AdipogenesisSemantic proximity Read

Pharmacological Evaluation of Bergapten in High Fat Diet and Letrozole Induced Polycystic Ovarian Syndrome in Wistar RatsSemantic proximity Read

Unraveling the physiological roles of retinoic acid receptor-related orphan receptor αSemantic proximity Read

The obesity-induced transcriptional regulator TRIP-Br2 mediates visceral fat endoplasmic reticulum stress-induced inflammationSemantic proximity Read

Activation of PPARγ by a Natural Flavonoid Modulator, Apigenin Ameliorates Obesity-Related Inflammation Via Regulation of Macrophage Polarization.Semantic proximity Read

Zebrafish and Flavonoids: Adjuvants against ObesitySemantic proximity Read