Article

Single-nucleus co-expression networks of dopaminergic neurons support iron accumulation as a plausible explanation to their vulnerability in Parkinson’s disease

2022-12-15

Abstract excerpt

<h4>Motivation</h4> gene co-expression networks have been widely applied to identify critical genes and pathways for neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease. Now, with the advent of single-cell RNA-sequencing, we have the opportunity to create cell-type specific gene co-expression networks. However, single-cell RNA-sequencing data is characterized by its sparsity, amongst some other...

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Literature Corpus work: 12f6dfb3-45e3-5aae-bdc2-fe29d6ea3f86
DOI: 10.1101/2022.12.13.514863

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