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Article

Total RNA-seq as a Tool to Study DMD Splicing and Transcriptional Dynamics.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2026

Dunn Diane M, Weiss Robert B

Abstract excerpt

Advances in RNA analysis of dystrophin (DMD) mutations have been significantly influenced by improvements in methods to study mRNA transcription and splicing. Early breakthroughs, such as the 1988 cDNA sequencing of the 14-kb muscle transcript isoform of the dystrophin gene, paved the way for RNA-based mutation detection via RT-PCR. These studies revealed that point mutations often cause premature polypeptide...

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Share to Dystrophin
Share to Gene Expression Profiling
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscular Dystrophy, Duchenne

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Identifiers

PMID: 41028306
DOI: 10.1007/978-1-0716-4811-7_2

Genes

DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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