Article

Liver-specific in vivo base editing of Angptl3 via AAV delivery efficiently lowers blood lipid levels in mice

2023-03-07

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: Gene editing has emerged as an exciting therapeutic development platform for numerous genetic and nongenetic diseases. Targeting lipid-modulating genes such as angiopoietin-related protein 3 (ANGPTL3) with gene editing offers hope for a permanent solution to lower cardiovascular disease risks associated with hypercholesterolemia. <bold>Results</bold>: In this st...

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Literature Corpus work: 947910fd-a556-599d-b8c4-caead408417f
DOI: 10.21203/rs.3.rs-2592180/v1

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