Article

Fasting-mimicking diet counteracts gut microbial dysbiosis in experimental Lynch syndrome

2025-03-17

Abstract excerpt

The development of colorectal cancer (CRC) is largely influenced by hereditary factors, with up to one-third of cases linked to genetic predisposition. In parallel, environmental factors such as diet and intestinal microbiota play a significant role. Lynch syndrome (LS), the most common form of hereditary CRC, is due to mutations in DNA mismatch repair genes. Diet interventions such as calorie restriction (CR) can...

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Literature Corpus work: 1273c57e-a171-5468-8130-5a8fda184fab
DOI: 10.1101/2025.03.14.643045

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