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Prioritization of chemical scaffolds using the TDR Targets database: an integrative workflow for <i>Trypanosoma cruzi</i> drug discovery

2026-03-03

Abstract excerpt

Chagas disease, caused by the parasite Trypanosoma cruzi , faces a critical innovation gap in drug development, with current treatments hindered by toxicity and limited efficacy. To address this, we implemented an integrative chemogenomic workflow using the TDR Targets database to prioritize drug candidates. To prioritize repurposing candidates for T. cruzi , we designed a query to retrieve compounds active agai...

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Identifiers and source

Literature Corpus work
12534e57-be9a-5878-8b79-38a6828c3066
DOI
10.64898/2026.03.02.709050
Open publication

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Prioritization of chemical scaffolds using the TDR Targets database: an integrative workflow for <i>Trypanosoma cruzi</i> drug discoveryDOI 10.64898/2026.03.02.709050
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