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Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery

26 Jun 2015

Abstract excerpt

BACKGROUND: Chagas disease is a neglected tropical disease (NTD) caused by the eukaryotic parasite Trypanosoma cruzi. The current clinical and preclinical pipeline for T. cruzi is extremely sparse and lacks drug target diversity. METHODOLOGY/PRINCIPAL FINDINGS: In the present study we developed a computational approach that utilized data from several public whole-cell, phenotypic high throughput screens that have...

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PMID: 26114876
DOI: 10.1371/journal.pntd.0003878

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