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Global lessons from antibiotic resistance: metformin-hydrolyzing genes in transposable elements, a new threat for type II diabetic patients?

2025-04-28

Abstract excerpt

Metformin drug, widely used to treat type II diabetic patients, is a major pharmaceutical pollutant of wastewater and rivers. This environmental exposure has driven the evolution of bacteria, such as Aminobacter and Pseudomonas , to degrade metformin via a Ni²⁺-dependent metformin hydrolase complex (MfmAB). Here we decipher the mechanism of acquisition and horizontal transfer of the mfmAB genes, initially mobil...

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Literature Corpus work
12315d0e-4727-51ca-92fa-e3eeb1a667db
DOI
10.1101/2025.04.28.651035
Open publication

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Global lessons from antibiotic resistance: metformin-hydrolyzing genes in transposable elements, a new threat for type II diabetic patients?DOI 10.1101/2025.04.28.651035
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