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Global dissemination of npmA mediated pan-aminoglycoside resistance via a novel mobile genetic element in Gram-positive bacteria

2024-05-16

Abstract excerpt

<title>Abstract</title> <p>The <italic>npmA</italic> gene, encoding a 16S rRNA methyltransferase, confers resistance to all clinically available aminoglycosides, posing a significant threat to effective antibiotic therapy. Here, we investigated the distribution and mobilization mechanisms of <italic>npmA</italic> variants, <italic>npmA1</italic> and <italic>npmA2</italic>, through an exhaustive analysis of 692,64...

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Literature Corpus work
bd7b7dc4-b315-5b89-9c4c-ae5aa92eda67
DOI
10.21203/rs.3.rs-4394742/v1
Open publication

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Global dissemination of npmA mediated pan-aminoglycoside resistance via a novel mobile genetic element in Gram-positive bacteriaDOI 10.21203/rs.3.rs-4394742/v1
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