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Global dissemination of npmA mediated pan-aminoglycoside resistance via a mobile genetic element in Gram-positive bacteria

17 Jul 2025

Abstract excerpt

The npmA gene, encoding a 16S rRNA methyltransferase, confers resistance to all clinically available aminoglycosides, posing a significant threat to effective antibiotic therapy. We analyze 1,932,812 bacterial genomes to investigate the distribution and mobilization of npmA variants. npmA is not found in Gram-negative bacteria, where it was originally described, but is identified among Gram-positive bacteria,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40675954
DOI: 10.1038/s41467-025-61152-y

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