Article

Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis

2020-11-12

Abstract excerpt

Biological therapies have transformed the management of psoriasis but clinical outcome is variable leaving an unmet clinical need for predictive biomarkers of response. To identify the immune determinants of response to the anti-TNF drug adalimumab and evaluate their predictive value, we performed in-depth immunomonitoring of blood immune cells of 67 psoriasis patients, before and during therapy. We assessed proxi...

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Literature Corpus work: 122824f8-7d9c-535e-8588-b35ca7d80ac6
DOI: 10.1101/2020.11.09.20228502

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