Article

Knockdown of the E3 Ubiquitin ligase UBR5 and its role in skeletal muscle anabolism

2020-06-06

Abstract excerpt

UBR5 is an E3-ubiquitin-ligase positively associated with anabolism, hypertrophy and recovery from atrophy in skeletal muscle. The precise mechanisms underpinning UBR5’s role in the regulation of skeletal muscle mass remain unknown. The present study aimed to elucidate these mechanisms by silencing the UBR5 gene in-vitro and in-vivo . The siRNA-induced reduction (−77%) in UBR5 gene expression in human myotubes w...

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Literature Corpus work: 1152ba9c-ebd5-5f02-a9f8-28d4e8aef111
DOI: 10.1101/2020.06.05.116145

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