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Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice

30 Jan 2024

Abstract excerpt

Streptococcus anginosus (S. anginosus) was enriched in the gastric mucosa of patients with gastric cancer (GC). Here, we show that S. anginosus colonized the mouse stomach and induced acute gastritis. S. anginosus infection spontaneously induced progressive chronic gastritis, parietal cell atrophy, mucinous metaplasia, and dysplasia in conventional mice, and the findings were confirmed in germ-free mice. In...

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PMID: 38295787
DOI: 10.1016/j.cell.2024.01.004

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