Article

Identification of human tendon cell populations in healthy and diseased tissue using combined single cell transcriptomics and proteomics

2019-12-17

Abstract excerpt

The long-term morbidity of tendon disease in an increasingly active and ageing population represents a growing area of unmet clinical need. Tendon disorders commonly affect the lower limb, ranging from isolated tendon rupture to degenerative joint deformity. In the absence of valid animal models of chronic tendinopathy, traditional methods to isolate and identify crucial sub types involved in disease are limited b...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bd6ae329-7547-5810-b6d5-08c839786907
DOI: 10.1101/2019.12.09.869933

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of human tendon cell populations in healthy and diseased tissue using combined single cell transcriptomics and proteomicsDOI 10.1101/2019.12.09.869933Read

Multi-omic single cell analysis resolves novel stromal cell populations in healthy and diseased human tendonSemantic proximity Read

Single cell multi-omics characterise discrete human tendon cells populations that persist in vitro and on fibrous scaffoldsSemantic proximity Read

Combined single cell proteomics and transcriptomics reveals discrete human tendon cells populations persist in vitro and on fibrous scaffoldsSemantic proximity Read

Single-cell and spatial transcriptomics reveal changes in cell heterogeneity during progression of human tendinopathySemantic proximity Read

Multi-omics analysis of human tendon adhesion reveals ACKR1 migrates macrophages involve in endogenous regenerationSemantic proximity Read

Cellular and molecular landscapes of human tendons across the lifespan revealed by spatial and single-cell transcriptomicsSemantic proximity Read

Single nucleus and spatial transcriptomic profiling of healthy human hamstring tendonSemantic proximity Read

The Interfascicular Matrix of Energy Storing Tendons Houses Heterogenous Cell Populations Disproportionately Affected by AgingSemantic proximity Read

Single-cell transcriptomic analysis identifies extensive heterogeneity in the cellular composition of mouse Achilles tendonsSemantic proximity Read

Fibroblast specialisation across microanatomy in a single-cell atlas of healthy human Achilles tendonSemantic proximity Read

Multi-omics analysis of human tendon adhesion reveals that ACKR1-regulated macrophage migration is involved in regenerationSemantic proximity Read

Single-cell transcriptomic profiling reveals distinct mechanical responses between normal and diseased tendon progenitor cellsSemantic proximity Read