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Article

The role of Twist1 in mutant huntingtin-induced transcriptional alterations and neurotoxicity.

The Journal of biological chemistry - 27 Jul 2018

Pan Yanchun, Zhu Ying, Yang Wei, Tycksen Eric, Liu Shaopeng, Palucki John, Zhu Linjian, Sasaki Yo, Sharma Mukesh K, Kim Albert H, Zhang Bo, Yano Hiroko

Abstract excerpt

Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an abnormal expansion of polyglutamine repeats in the huntingtin protein (Htt). Transcriptional dysregulation is an early event in the course of HD progression and is thought to contribute to disease pathogenesis, but how mutant Htt causes transcriptional alterations and subsequent cell death in neurons is not well understood. RNA-Seq...

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Identifiers

PMID: 29891550
DOI: 10.1074/jbc.RA117.001211
PMCID: PMC6066321

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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