Article

Therapeutic interventions on human xenografts promote systemic dissemination of oncogenes

2023-04-06

Abstract excerpt

We generated xenografts of human cancer cells in mice, and using immuno-FISH analysis detected multiple co-localizing signals of human DNA and eight human oncoproteins in brain cells. Signals increased dramatically five days after treatment with chemotherapy, localized radiotherapy or surgery, which could be minimized by concurrent treatment with cell-free chromatin deactivating agents. These results suggest that...

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Literature Corpus work: 10df799a-6129-5875-9f4e-16bbbe9a6486
DOI: 10.1101/2023.04.06.535826

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