Article

Whole Exome Sequencing Reveals<i>FCGBP</i>Variant Associated with Spontaneous Intraabdominal Hemorrhage in Severe Acute Pancreatitis

2024-08-07

Abstract excerpt

This study sought to identify genetic cause of spontaneous intraabdominal hemorrhage (SIH) in severe acute pancreatitis (SAP) to develop more effective treatment for this life-threatening complication. A four-phase study was conducted, leveraging a large-scale acute pancreatitis (AP) patients (n=600); the first phase involved whole-exome sequencing analyses, and identified specific exonic variant located in FCGBP...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 10ae3320-6c0a-5813-94d3-bc0d9875469c
DOI: 10.1101/2024.08.06.24311443

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Whole Exome Sequencing Reveals<i>FCGBP</i>Variant Associated with Spontaneous Intraabdominal Hemorrhage in Severe Acute PancreatitisDOI 10.1101/2024.08.06.24311443Read

A multi-omics analysis of pancreatitis: bridging familial genetics and disease progression.Semantic proximity Read

Integration of scRNA-Seq and Bulk RNA-Seq Reveals Molecular Characterization of the Immune Microenvironment in Acute PancreatitisSemantic proximity Read

An integrated picture of chronic pancreatitis derived by mapping variants in multiple disease genes onto pathogenic pathways.Semantic proximity Read

Hypertriglyceridemic acute pancreatitis in emergency department: Typical clinical features and genetic variants.Semantic proximity Read

Proteome-Wide Mendelian Randomization Identifies Causal Links Between Blood Proteins and Acute Pancreatitis.Semantic proximity Read

Pancreatitis polygenic risk score is independently associated with all-cause acute pancreatitis risk in the UK Biobank.Semantic proximity Read

Heterozygous Spink1 c.194+2T>C mutation promotes chronic pancreatitis after acute attack in mice.Semantic proximity Read

Meta-analysis and field synopsis of genetic variants associated with the risk and severity of acute pancreatitis.Semantic proximity Read

Identification of novel biomarkers based on lipid metabolism-related molecular subtypes for moderately severe and severe acute pancreatitisSemantic proximity Read

Chronic pancreatitis, a comprehensive review and update. Part I: epidemiology, etiology, risk factors, genetics, pathophysiology, and clinical features.Semantic proximity Read

Aging- and alcohol-associated spatial transcriptomic signature in mouse acute pancreatitis reveals heterogeneity of inflammation and potential pathogenic factorsSemantic proximity Read

Whole exome sequencing identifies three novel gene mutations in patients with the triad of diabetic ketoacidosis, hypertriglyceridemia, and acute pancreatitis.Semantic proximity Read