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Article

TRIM59 is Suppressed by Androgen Receptor and Acts to Promote Lineage Plasticity and Neuroendocrine Differentiation in Prostate Cancer

2021-05-07

Abstract excerpt

<h4>Background: </h4> The incidence of treatment-induced neuroendocrine prostate cancer (t-NEPC) has been greatly increasing after the usage of second-generation androgen receptor (AR) pathway inhibitors (ARPIs). Neuroendocrine differentiation (NED) is closely associated with ARPI treatment failure and poor prognosis in prostate cancer (PCa) patients. However, the molecular mechanisms of NED are not fully understo...

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Literature Corpus work
107d5cc0-0771-5e25-af8e-a05ade7cdd2e
DOI
10.21203/rs.3.rs-470260/v1
Open publication

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TRIM59 is Suppressed by Androgen Receptor and Acts to Promote Lineage Plasticity and Neuroendocrine Differentiation in Prostate CancerDOI 10.21203/rs.3.rs-470260/v1
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