Article

Discovery and 3D imaging of a novel ΔNp63-expressing basal cell type in human pancreatic ducts with implications in disease

2020-08-20

Abstract excerpt

<h4>SUMMARY</h4> <h4>Objective</h4> An aggressive basal-like molecular subtype of pancreatic ductal adenocarcinoma (PDAC) exists, driven by ΔNp63. In other epithelia, ΔNp63 + basal cells have stem cell capacity and can be at the origin of tumors. In the pancreas, basal cells have not been identified. <h4>Design</h4> We assessed basal cell markers in human and mouse pancreas, chronic pancreatitis and PDAC, and...

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Literature Corpus work: 106c9cfe-69ff-5f19-aab9-5807529693c7
DOI: 10.1101/2020.08.20.259317

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