Article
BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts.
Cell reports - 28 Jun 2016
Kemper Kristel, Krijgsman Oscar, Kong Xiangjun, Cornelissen-Steijger Paulien, Shahrabi Aida, Weeber Fleur, van der Velden Daphne L, Bleijerveld Onno B, Kuilman Thomas, Kluin Roel J C, Sun Chong, Voest Emile E, Ju Young Seok, Schumacher Ton N M, Altelaar A F Maarten, McDermott Ultan, Adams David J, Blank Christian U, Haanen John B, Peeper Daniel S
Abstract excerpt
The therapeutic landscape of melanoma is improving rapidly. Targeted inhibitors show promising results, but drug resistance often limits durable clinical responses. There is a need for in vivo systems that allow for mechanistic drug resistance studies and (combinatorial) treatment optimization. Therefore, we established a large collection of patient-derived xenografts (PDXs), derived from BRAF(V600E), NRAS(Q61),...
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