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Lack of Functional Trehalase Activity in Candida Parapsilosis Increases Susceptibility to Itraconazole

2022-03-14

Abstract excerpt

Central metabolic pathways may play a major role in the virulence of pathogenic fungi. Here, we have investigated the susceptibility of a Candida parapsilosis mutant deficient in trehalase activity (atc1Δ/ntc1Δ strain) to the azolic compounds Fluconazole and Itraconazole. A time-course exposure to Itraconazole but not Fluconazole induced a significant degree of cell-killing in mutant cells compared to...

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Literature Corpus work
1037cf16-0f34-5a1a-b067-249102d1cb52
DOI
10.20944/preprints202203.0175.v1
Open publication

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Lack of Functional Trehalase Activity in Candida Parapsilosis Increases Susceptibility to ItraconazoleDOI 10.20944/preprints202203.0175.v1
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