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PKR-like ER kinase (PERK) Haplotypes Are Associated with Depressive Symptoms in People with HIV

2022-09-27

Abstract excerpt

<h4>Background: </h4> . Depression is a debilitating and difficult-to-treat condition in people with HIV (PWH) despite viral suppression on antiretroviral therapy (ART). Depression is associated with activation of the PKR-like ER kinase (PERK) pathway, which regulates protein synthesis in response to metabolic stress. We evaluated common PERK haplotypes that influence PERK expression in relation to depressed mood...

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Identifiers and source

Literature Corpus work
10377e55-41e0-5527-bf7c-c3b792d1c16a
DOI
10.21203/rs.3.rs-2052794/v1
Open publication

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