Article
CYP2B6 Genetic Polymorphisms, Depression, and Viral Suppression in Adults Living with HIV Initiating Efavirenz-Containing Antiretroviral Therapy Regimens in Uganda: Pooled Analysis of Two Prospective Studies.
AIDS research and human retroviruses - 1 Nov 2018
Chang Jonathan L, Lee Sulggi A, Tsai Alexander C, Musinguzi Nicholas, Muzoora Conrad, Bwana Bosco, Boum Yap, Haberer Jessica E, Hunt Peter W, Martin Jeff, Bangsberg David R, Kroetz Deanna L, Siedner Mark J
Abstract excerpt
Single-nucleotide polymorphisms (SNPs) in CYP2B6 have been shown to predict variation in plasma efavirenz concentrations, but associations between these SNPs and efavirenz-mediated depression and viral suppression are less well described. We evaluated three SNPs in CYP2B6 (rs3745274, rs28399499, and rs4803419) in Ugandan persons living with HIV. To define exposure, we used previously published pharmacokinetic...
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