Article
Structure of a Plasmodium falciparum PfEMP1 rosetting domain reveals a role for the N-terminal segment in heparin-mediated rosette inhibition.
Proceedings of the National Academy of Sciences of the United States of America - 29 Mar 2011
Juillerat Alexandre, Lewit-Bentley Anita, Guillotte Micheline, Gangnard Stéphane, Hessel Audrey, Baron Bruno, Vigan-Womas Inès, England Patrick, Mercereau-Puijalon Odile, Bentley Graham A
Abstract excerpt
The human malaria parasite Plasmodium falciparum can cause infected red blood cells (iRBC) to form rosettes with uninfected RBC, a phenotype associated with severe malaria. Rosetting is mediated by a subset of the Plasmodium falciparum membrane protein 1 (PfEMP1) variant adhesins expressed on the infected host-cell surface. Heparin and other sulfated oligosaccharides, however, can disrupt rosettes, suggesting...
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