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Multiscale modeling of the spatial structure of stem cells in neuroblastoma patient-derived tumoroids reveals a critical role for a short range diffusive process

2025-07-29

Abstract excerpt

Neuroblastomas are heterogeneous pediatric tumors of the sympathetic nervous system for which treatments are still limited. Fundamental and applied approaches have been enabled thanks to the generation of patient-derived tumoroids (PDTs), ex vivo 3D structures used as avatars of the original tumor. We generated neuroblastoma PDTs and quantified the spatial distribution of CD133 + cancer stem cells using immunoh...

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Literature Corpus work
0fbe19ab-f4bc-5064-8472-eccdc79fd183
DOI
10.1101/2025.07.24.666524
Open publication

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Multiscale modeling of the spatial structure of stem cells in neuroblastoma patient-derived tumoroids reveals a critical role for a short range diffusive processDOI 10.1101/2025.07.24.666524
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