Drosophila UBE3A regulates satiety signaling through the Piezo mechanosensitive ion channel

Abstract excerpt

<title>Abstract</title> <p> Angelman syndrome (AS) is a rare neurogenetic disorder characterized by developmental delays, speech impairments, ataxic movements, and in some cases, hyperphagic feeding behavior. Loss of function mutations, loss of expression from the maternal allele or absence of maternal UBE3A result in AS. Recent studies have established a connection between <italic>UBE3A</italic> and the mecha...

Topics

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• Alleles
• Angelman Syndrome
• Disease Models, Animal
• Intellectual Disability
• Ion Channels
• Linoleic Acid
• Mice
• Ubiquitin-Protein Ligases

Identifiers and source

Literature Corpus work

0fa84cae-0e71-50ed-8e0f-67e625bf049d

DOI

10.21203/rs.3.rs-3101314/v1