Article

Dissecting organoid-bacteria interaction highlights decreased contractile force as a key factor for heart infection

2025-04-14

Abstract excerpt

Bacterial endocarditis is a fatal cardiovascular disease exacerbated by weakened heart contraction, yet the direct impact of cardiac contractility on bacterial adhesion remains elusive. Here, we present a novel quantitative physics model integrating finite element analysis and live-cell imaging to uncover their strong correlation. Using this model, we quantified the real-time force magnitude generated by organoid-...

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Literature Corpus work: 0f5f1522-84c9-59aa-9e32-83cb17517d04
DOI: 10.1101/2025.04.08.647814

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