Article

The chemotherapeutic drug methotrexate selects for antibiotic resistance

2020-11-12

Abstract excerpt

Understanding drivers of antibiotic resistance evolution is fundamental for designing optimal treatment strategies and interventions to reduce the spread of antibiotic resistance. Various cytotoxic drugs used in cancer chemotherapy have antibacterial properties, but how bacterial populations are affected by these selective pressures is unknown. Here we test the hypothesis that the widely used cytotoxic drug methot...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0f5e7b94-071e-53d7-a708-0f307ce25000
DOI: 10.1101/2020.11.12.378059

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The chemotherapeutic drug methotrexate selects for antibiotic resistanceDOI 10.1101/2020.11.12.378059Read

Multidrug evolutionary strategies to reverse antibiotic resistance.Semantic proximity Read

An evolutionary explanation for antibiotics’ association with increased colon cancer riskSemantic proximity Read

Prolonged Antibiotic Treatment Generates a Fluoroquinolone Resistant Gut Microbiome and Collateral Multi-Drug ResistanceSemantic proximity Read

The anticancer chemotherapy drug 5-Fluorouracil has positive interaction with antibiotics and can select for antibiotic resistance in <i>Staphylococcus aureus</i>Semantic proximity Read

Selection of a Multidrug Resistance Plasmid by Sublethal Levels of Antibiotics and Heavy MetalsSemantic proximity Read

Tazobactam selects for multidrug resistanceSemantic proximity Read

Mutation and evolution of antibiotic resistance: antibiotics as promoters of antibiotic resistance?Semantic proximity Read

Antibiotic resistance in microbes.Semantic proximity Read

Early-life exposure to multiple micronutrient deficiencies induces clinically-relevant antibiotic resistance in a pre-clinical murine modelSemantic proximity Read

Antibiotics and antibiotic resistance: a bitter fight against evolution.Semantic proximity Read

The role of heavy metals in the co-selection of plasmid-borne metal and antibiotic resistance genes from industrially contaminated sedimentsSemantic proximity Read

Antibiotic resistance and virulence: Understanding the link and its consequences for prophylaxis and therapySemantic proximity Read