Article

Recombinant annexin A6 promotes membrane repair in a stem cell derived-cardiomyocyte model of dystrophic cardiomyopathy

2022-03-11

Abstract excerpt

<h4>ABSTRACT</h4> Heart failure is a major source of mortality in Duchenne muscular dystrophy (DMD). DMD arises from mutations that ablate expression of the protein dystrophin, which render the plasma membrane unusually fragile and prone to disruption. In DMD patients, repeated mechanical stress leads to membrane damage and cardiomyocyte loss. Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) offer...

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Literature Corpus work: 0f20053f-8e43-5089-b0a9-5b99fca290d0
DOI: 10.1101/2022.03.09.483528

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