Article

Why is <i>Babesia</i> not killed by artemisinin like <i>Plasmodium</i> ?

2022-08-01

Abstract excerpt

Babesia spp. are intraerythrocytic apicomplexan organisms digesting hemoglobin similar to intraerythrocytic Plasmodium spp. However, unlike Plasmodium spp., Babesia spp. are not sensitive to artemisinin, The difference between Babesia genomes and Plasmodium genomes revealed that smaller Babesia genomes lack numerous genes, especially haem synthesis-related genes. Single-cell sequencing analysis showed that d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 05238242-5090-5ab1-9a77-6ae3655f6e8f
DOI: 10.1101/2022.08.01.502256

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Why is <i>Babesia</i> not killed by artemisinin like <i>Plasmodium</i> ?DOI 10.1101/2022.08.01.502256Read

Decoding The Nuclear Genome of The Human Pathogen <i>Babesia duncani</i> Shed Light on its Virulence, Drug Susceptibility and Evolution among ApicomplexaSemantic proximity Read

Elusive <i>Plasmodium</i> Species Complete the Human Malaria Genome SetSemantic proximity Read

Heme-deficient metabolism and impaired cellular differentiation as an evolutionary trade-off for human infectivity in <i>Trypanosoma brucei gambiense</i>Semantic proximity Read

Supply and demand—heme synthesis, salvage and utilization by ApicomplexaSemantic proximity Read

Heme-deficient metabolism and impaired cellular differentiation as an evolutionary trade-off for human infectivity in Trypanosoma brucei gambienseSemantic proximity Read

Multiomics analysis reveals <i>B.</i> MO1 as a distinct <i>Babesia</i> species and provides insights into its evolution and virulenceSemantic proximity Read

Host metabolic pathways essential for malaria and related hemoparasites in the infection of nucleated cellsSemantic proximity Read

Insights into the phylogenetic relationships and drug targets of Babesia isolates infective to small ruminants from the mitochondrial genomesSemantic proximity Read

Adaptive iron utilization compensates for the lack of an inducible uptake system in <i>Naegleria fowleri</i> and represents a potential target for therapeutic interventionSemantic proximity Read

Plasmodium—a brief introduction to the parasites causing human malaria and their basic biologySemantic proximity Read

Single-cell RNA profiling of <i>Plasmodium vivax</i> -infected hepatocytes reveals parasite- and host- specific transcriptomic signatures and therapeutic targetsSemantic proximity Read

An overview of the Babesia, Plasmodium and Theileria genomes: A comparative perspectiveSemantic proximity Read