Article

Meta-analysis of transcriptomes of SARS-Cov2 infected human lung epithelial cells identifies transmembrane serine proteases co-expressed with ACE2 and biological processes related to viral entry, immunity, inflammation and cellular stress

2020-05-13

Abstract excerpt

The COVID-19 pandemic resulting from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which emerged in December 2019 in the Chinese city of Wuhan in the province Hubei has placed immense burden on national economies and global health. At present neither vaccination nor therapies are available although several antiviral agents such as remdesivir, originally an Ebola drug, nelfinavir, an HIV-1 protea...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0db24fef-432a-587e-962c-92f8da3cc78a
DOI: 10.1101/2020.05.12.091314

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Meta-analysis of transcriptomes of SARS-Cov2 infected human lung epithelial cells identifies transmembrane serine proteases co-expressed with ACE2 and biological processes related to viral entry, immunity, inflammation and cellular stressDOI 10.1101/2020.05.12.091314Read

SARS-CoV-2 receptor ACE2 is co-expressed with genes related to transmembrane serine proteases, viral entry, immunity and cellular stressSemantic proximity Read

Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronavirusesSemantic proximity Read

Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cellsSemantic proximity Read

Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 infection induces dysregulation of immunity: in silico gene expression analysisSemantic proximity Read

Single-cell RNA expression profiling of ACE2, the receptor of SARS-CoV-2Semantic proximity Read

Identifying pathways and networks associated with the SARS-CoV-2 cell receptor ACE2 based on gene expression profiles in human tissuesSemantic proximity Read

Gene Expression Profiling Reveals the Shared and Distinct Transcriptional Signatures in Human Lung Epithelial Cells Infected With SARS-CoV-2, MERS-CoV, or SARS-CoV: Potential Implications in Cardiovascular Complications of COVID-19Semantic proximity Read

Single-Cell RNA Expression Profiling of ACE2, the Receptor of SARS-CoV-2Semantic proximity Read

Comprehensive comparison of transcriptomes in SARS-CoV-2 infection: alternative entry routes and innate immune responsesSemantic proximity Read

SARS-CoV-2 activates lung epithelia cell proinflammatory signaling and leads to immune dysregulation in COVID-19 patients by single-cell sequencingSemantic proximity Read

Comparative transcriptome analyses reveal genes associated with SARS-CoV-2 infection of human lung epithelial cellsSemantic proximity Read

Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2Semantic proximity Read