Article

Spatiotemporal coordination at the maternal-fetal interface promotes trophoblast invasion and vascular remodeling in the first half of human pregnancy

2021-09-10

Abstract excerpt

Beginning in the first trimester, fetally derived extravillous trophoblasts (EVTs) invade the uterus and remodel its spiral arteries, transforming them into large, dilated blood vessels left with a thin, discontinuous smooth muscle layer and partially lined with EVTs. Several mechanisms have been proposed to explain how EVTs coordinate with the maternal decidua to promote a tissue microenvironment conducive to spi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0d5afa10-6b51-5268-8933-cf7e52deaf16
DOI: 10.1101/2021.09.08.459490

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatiotemporal coordination at the maternal-fetal interface promotes trophoblast invasion and vascular remodeling in the first half of human pregnancyDOI 10.1101/2021.09.08.459490Read

A spatially resolved timeline of the human maternal–fetal interfaceSemantic proximity Read

Dynamic Spiral Artery Remodeling in Early Human Pregnancy: An Analysis of Specimens Collected with a Standardized ProtocolSemantic proximity Read

Spatially resolved single-cell multiomics map of human trophoblast differentiation in early pregnancySemantic proximity Read

Spatial multiomics map of trophoblast development in early pregnancySemantic proximity Read

Function and control of human invasive trophoblast subtypes: Intrinsic vs. maternal controlSemantic proximity Read

Single-cell and spatial transcriptomics reveal alterations in trophoblasts at invasion sites and disturbed myometrial immune microenvironment in placenta accreta spectrum disordersSemantic proximity Read

Conservation at the uterine-placental interfaceSemantic proximity Read

Crosstalk between Placental Trophoblast and Decidual Immune Cells in Recurrent MiscarriageSemantic proximity Read

Genome-wide expression profile of first trimester villous and extravillous human trophoblast cellsSemantic proximity Read

Temporal placental genome wide expression profiles reflect three phases of utero-placental blood flow during early to mid human gestationSemantic proximity Read

Deciphering the Intercellular Communication Network of Peripartum Decidua that Orchestrates DeliverySemantic proximity Read

Conservation at the uterine–placental interfaceSemantic proximity Read