Article

DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation

2023-04-05

Abstract excerpt

Pyrimidine nucleotide biosynthesis is a druggable metabolic dependency of cancer cells, and chemotherapy agents targeting pyrimidine metabolism are the backbone of treatment for many cancers. Dihydroorotate dehydrogenase (DHODH) is an essential enzyme in the de novo pyrimidine biosynthesis pathway that can be targeted by clinically approved inhibitors. However, despite robust preclinical anticancer efficacy, DHODH...

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Literature Corpus work: 0d3d7453-3668-5180-801e-59b20270dced
DOI: 10.1101/2023.04.03.535399

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