Article

Crystal structures of 17-beta-hydroxysteroid dehydrogenase 13

2023-04-20

Abstract excerpt

Hydroxysteroid 17-beta-dehydrogenase 13 (HSD17B13) is a hepatic lipid droplet-associated enzyme that is upregulated in patients with non-alcoholic fatty liver disease. Recently, there have been several reports that predicted loss of function variants in HSD17B13 protect against the progression of steatosis to non-alcoholic steatohepatitis with fibrosis and hepatocellular carcinoma. Here we report the first known c...

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Literature Corpus work: 0c5a59a5-eae2-56a9-a3a9-310434aefe9f
DOI: 10.21203/rs.3.rs-2688507/v1

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