Article

Whole-genome sequencing analysis of left ventricular structure and sphericity in 80,000 people

2025-08-26

Abstract excerpt

<h4>Background</h4> Sphericity is a measurement of how closely an object approximates a globe. The sphericity of the blood pool of the left ventricle (LV), is an emerging measure linked to myocardial dysfunction. <h4>Methods</h4> Video-based deep learning models were trained for semantic segmentation (pixel labeling) in cardiac magnetic resonance imaging in 84,327 UK Biobank participants. These labeled pixels we...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0bf5fb9c-eb81-56b3-b394-529eb09c1483
DOI: 10.1101/2025.08.22.25334019

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Whole-genome sequencing analysis of left ventricular structure and sphericity in 80,000 peopleDOI 10.1101/2025.08.22.25334019Read

Deep learning enabled analysis of cardiac sphericitySemantic proximity Read

Analysis of cardiac magnetic resonance imaging traits in 29,000 individuals reveals shared genetic basis with dilated cardiomyopathySemantic proximity Read

Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy.Semantic proximity Read

Population genomics of four-dimensional cardiac motion reveals non-myocyte regulatory programmesSemantic proximity Read

Differences in Cardiac Mechanics among Genetically At-Risk First-Degree Relatives: The DCM Precision Medicine StudySemantic proximity Read

Genome-Wide Analysis of Left Ventricular Image-Derived Phenotypes Identifies Fourteen Loci Associated With Cardiac Morphogenesis and Heart Failure DevelopmentSemantic proximity Read

Using Machine Learning to Elucidate the Spatial and Genetic Complexity of the Ascending AortaSemantic proximity Read

Genomic analysis reveals a functional role for myocardial trabeculae in adultsSemantic proximity Read

Machine Learning-Derived Cardiovascular Aging Phenotypes From Cardiac Function and Stroke Risk in the UK Biobank: Cohort Study.Semantic proximity Read

Three-dimensional cardiovascular imaging-genetics: a mass univariate framework.Semantic proximity Read

Deep-learning analysis of 3D microarchitectural remodeling in hypertrophic cardiomyopathy.Semantic proximity Read

New Genetic Loci Implicated in Cardiac Morphology and Function Using Three-Dimensional Population Phenotyping.Semantic proximity Read