Article

Sample-Index Misassignment Impacts Tumor Exome Sequencing

2017-09-01

Abstract excerpt

Sample pooling enabled by dedicated indexes is a common and cost-effective strategy used in high-throughput DNA sequencing. Index misassignment leading to cross-sample contamination has however been described as a general problem of sequencing instruments which utilize exclusion amplification. Using real-life data from multiple tumor sequencing projects, we demonstrate that co-multiplexed samples can induce artifa...

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Literature Corpus work: 0bd2d2bb-be90-5ad2-81cb-42ec13d7361c
DOI: 10.1101/182659

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