Article

Exploiting Index Cross-Talk to Modify Variant Calls

2018-05-28

Abstract excerpt

Modern next-generation DNA sequencers support multiplex sequencing to improve throughput and decrease costs. This is done by pooling and sequencing samples together in parallel, which are later demultiplexed according to their unique indexes 1, 2 . When reads are assigned to the wrong index, called index cross-talk, information is leaked between samples 3–6 . This creates a physical information side-channel, a w...

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Literature Corpus work: 03d56827-4c01-53c0-9c95-5430e09eeee0
DOI: 10.1101/332346

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