Article
Mutations in the human alpha-tectorin gene cause autosomal dominant non-syndromic hearing impairment.
Nature genetics - 1 May 1998
Verhoeven K, Van Laer L, Kirschhofer K, Legan P K, Hughes D C, Schatteman I, Verstreken M, Van Hauwe P, Coucke P, Chen A, Smith R J, Somers T, Offeciers F E, Van de Heyning P, Richardson G P, Wachtler F, Kimberling W J, Willems P J, Govaerts P J, Van Camp G
Abstract excerpt
The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major non-collagenous components of the...
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