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Article

Characterization of a spontaneous, recessive, missense mutation arising in the Tecta gene.

Journal of the Association for Research in Otolaryngology : JARO - 1 Jun 2008

Moreno-Pelayo Miguel Angel, Goodyear Richard J, Mencía Angeles, Modamio-Høybjør Silvia, Legan P Kevin, Olavarrieta Leticia, Moreno Felipe, Richardson Guy P

Abstract excerpt

The TECTA gene encodes alpha-tectorin (TECTA), a major noncollagenous component of the tectorial membrane (TM). In humans, mutations in TECTA lead to either dominant (DFNA8/A12) or recessive (DFNB21) forms of nonsyndromic hearing loss. All missense mutations in TECTA that have been reported thus far are associated with the dominant subtype, whereas those leading to recessive deafness are all inactivating...

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Source

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Identifiers

PMID: 18452040
DOI: 10.1007/s10162-008-0116-0
PMCID: PMC2504605

Genes

TECTA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Characterization of a spontaneous, recessive, missense mutation arising in the Tecta gene.PMID 18452040Read ↗

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