Article

Respiratory syncytial virus load-dependent ciliated cell dedifferentiation and downregulation of immune response genes

2025-08-01

Abstract excerpt

Respiratory syncytial virus (RSV) can cause severe lower respiratory tract infections in infants, older adults, and individuals with chronic or immunocompromising conditions. To understand how RSV affects airway cells, we infected primary human airway epithelial cultures with RSV and analyzed infected and bystander cells using time-resolved single-cell RNA sequencing and imaging. RSV mainly infected ciliated cells...

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Literature Corpus work: 0b450178-861c-5d4d-9cfd-edfe068505f0
DOI: 10.1101/2025.08.01.666372

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